NFL: 49ers vs Philadelphia Eagles - Odds, Prediction & Picks

In a clash of titans at Lincoln Financial Field on Sunday, December 3, 2023, the San Francisco 49ers (8-3) take on the Philadelphia Eagles (10-1) at 4:25 PM ET. The 49ers, coming off three consecutive wins, are favored by 3 points, with a moneyline of -165, while the Eagles, riding a five-game win streak, have a moneyline of +140 at Caesars Sportsbook.

This pivotal matchup could determine the NFC's top seed. The 49ers boast a formidable defense, allowing the fewest points per game (15.5), while the Eagles, despite recent defensive struggles, remain unbeaten with Jalen Hurts leading the charge. With playoff implications on the line, both teams will battle fiercely for supremacy in this highly anticipated NFC Championship Game rematch.

The 49ers face uncertainties with key players like Jordan Mason, Ray-Ray McCloud, and Arik Armstead listed as questionable. On the Eagles' side, crucial players like Justin Evans, Zach Cunningham, and Dallas Goedert face injury concerns, adding a layer of complexity to this showdown. As the stakes are high, NFL bettors can expect a clash of offensive prowess and defensive resilience in a game that could shape the narrative of the NFC playoff race.

Odds provided by Caesars Sportsbook

Philadelphia Eagles

TThe Eagles (10-1) enter the clash against the 49ers with impressive momentum, riding a five-game win streak. Their dynamic offense led by Jalen Hurts, paired with a resilient defense, has propelled them to the top of the NFC. However, injuries to key players like Justin Evans and Zach Cunningham could pose challenges.

Philadelphia Eagles Injury Report:

• Justin Evans (S) - Out
• Zach Cunningham (LB) - Out
• Dallas Goedert (TE) - Doubtful
• Fletcher Cox (DT) - Questionable
• Grant Calcaterra (TE) - Questionable
• Lane Johnson (OT) - Questionable
• Jordan Davis (DT) - Questionable
• Milton Williams (DT) - Questionable

San Francisco 49ers

The 49ers (8-3) are on a three-game winning streak, boasting a dominant defense and a potent offense. However, key players like Jordan Mason and Arik Armstead face uncertainties due to injuries, potentially impacting the team's performance.

San Francisco 49ers Injury Report:

• Jordan Mason (RB) - Questionable
• Ray-Ray McCloud (WR) - Questionable
• Arik Armstead (DL) - Questionable
• Spencer Burford (OL) - Questionable
• Trent Williams (OT) - Unknown
• Nick Bosa (DL) - Unknown

Head-to-Head: 

In their recent encounters, the Eagles have emerged victorious in three out of the last five matchups against the 49ers.

Two Things for PA Football Bettors  to Know:

• Eagles' Offensive Prowess: Philadelphia boasts the league's fifth-best scoring offense, led by Jalen Hurts, with an average of 28.2 points per game.
• 49ers' Defensive Fortitude: San Francisco's defense is a formidable force, allowing the fewest points per game in the NFL at 15.5, presenting a significant challenge for the Eagles

In a clash between the Philadelphia Eagles (10-1) and the San Francisco 49ers (8-3), the Eagles aim to maintain their dominant form. Riding a five-game winning streak, the Eagles, led by quarterback Jalen Hurts, have showcased a potent offense averaging 28.2 points per game. Despite facing a resilient 49ers defense, the Eagles' dynamic rushing attack and Hurts' dual-threat ability present a formidable challenge.

The point spread at Caesars favors the 49ers (-3), but considering the Eagles' consistent covering of spreads, bettors should take note. The moneyline shows odds of Eagles (+140) and 49ers (-165), reflecting the Eagles' status as underdogs. Given the Eagles' recent successes and their perfect 4-0 record at home, taking them on the moneyline could offer value.

With a Total set at 48 points, expect an offensive showdown. Both teams possess potent attacks, suggesting the Over might be a prudent choice. The Eagles' recent ability to score consistently and the 49ers' offensive resurgence make this matchup promising for an entertaining, high-scoring affair.

In conclusion, while the 49ers present a formidable challenge, the Eagles' recent performances, especially at home, make them a strong contender. PA NFL bettors should consider taking the Eagles against the spread, on the moneyline for potential upset value, and betting on the Over for an exciting offensive showcase.

Total Points Over | Caesars -110

The best bet for the Eagles vs. 49ers matchup lies in the Over 48 Total Points market offered by Caesars at -110 odds. Both teams boast high-scoring offenses, with the Eagles averaging 28.2 points per game and the 49ers notching 28.2 as well. 

Considering their recent form and the offensive capabilities of quarterbacks Jalen Hurts and Brock Purdy, expect a point-heavy contest. The Over has hit in six of the Eagles' games and five of the 49ers' matchups this season. 

With a relatively modest Total set at 48 points, this bet provides a strong balance of value and probability for an exciting, high-scoring clash between these NFC powerhouses.