NFL: Pittsburgh Steelers vs SF 49ers – Odds, Prediction & Picks

The San Francisco 49ers will open the 2023 NFL season against the Pittsburgh Steelers at Acrisure Stadium on Sunday, September 10, with a 10 a.m. PT kickoff. This matchup features emerging quarterbacks, Brock Purdy and Kenny Pickett, while the return of Nick Bosa boosts the 49ers.

Key players to watch include Purdy, Pickett, Bosa, T.J. Watt, and Deebo Samuel. The 49ers are favored with a spread of -2.5 (-108) at FanDuel PA Sportsbook, and they seek to kick off the season with a win in what promises to be an exciting Week 1 clash.

Pittsburgh Steelers vs SF 49ers Analysis

San Francisco 49ers

The 49ers are entering the 2023 NFL season with high expectations, led by emerging quarterback Brock Purdy. They aim to build on last season's success, reaching the NFC Championship Game. However, their star player, Nick Bosa, has been listed as questionable due to injury.

Pittsburgh Steelers

The Steelers are looking to make a strong start to the season under the leadership of quarterback Kenny Pickett. They hope to be a playoff contender but face a challenging opener against the 49ers. The key defender, T.J. Watt, is expected to play after recovering from an injury and is crucial to their defensive success.

Pittsburgh Steelers vs SF 49ers Match Prediction

First and foremost, recent form is on the Steelers' side. They finished the previous season with a strong four-game winning streak, showcasing their ability to close out games effectively. This momentum can carry over into the new season and boost their confidence.

In terms of previous meetings, it's true that the 49ers secured a victory in their last encounter in 2019. However, a lot has changed since then. The Steelers have undergone improvements in both their offense and defense, making them a more well-rounded team.

Spread: The spread currently favors the 49ers at -2.5 (-108) at Pennsylvania FanDuel Sportsbook, but the Steelers have a strong chance of covering this. With a revamped offense led by Kenny Pickett and promising rookie George Pickens, they can keep the game close and potentially even win outright.

Moneyline: The Steelers, with their potential for an upset, present an enticing bet at +112. If they can execute their game plan effectively and capitalize on any turnovers, a Moneyline wager on the Steelers could yield a profitable outcome.

Over/Under: Given the potential for a competitive matchup and both teams having offensive firepower, taking the Over might be a wise.

Pittsburgh Steelers vs SF 49ers Best Bet:

Moneyline + Steelers to win (+112) | FanDuel Sportsbook

The best bet for this matchup is for the Steelers to win on the Moneyline at odds of +114 with PA FanDuel Sportsbook. While the 49ers are favored, the Steelers have shown form throughout training camp and improvements that make them a strong value bet.

With a potentially explosive offense led by Kenny Pickett and appealing odds, backing the Steelers to secure an upset victory is a smart wager with an enticing potential payout.